Study Highlights Benefits of Pure Honokiol for Neurological Health

Study Highlights Benefits of Pure Honokiol for Neurological Health

With the rise in neurodegenerative conditions like Alzheimer’s and Parkinson’s disease, more practitioners and patients are relying on natural compounds to promote healthy cerebral and neurological function, without dangerous side effects.

One supplement that’s gaining attention in this area is pure honokiol, a powerful extract derived from Magnolia Officinalis bark. Extensive research shows honokiol offers important benefits to neurological health through multiple mechanisms, including supporting cell regulatory processes and promoting favorable gene expression. Honokiol also promotes relaxation and healthy mood through interaction with GABA receptors.

The Guardian of Human Lifespan

One fascinating study using pure honokiol demonstrated that it supports neurons during oxidative stress. Published June 2018 in the medical journal, ACS Chemical Neuroscience, researchers reported that honokiol supports against oxidation-induced cell death in PC12 cells (a specific line of nerve cells), by elevating glutathione levels and up-regulating a number of protective proteins.

Furthermore, the researchers demonstrated that honokiol activates the Nrf2 pathway, offering critical antioxidant protection. Nrf2 is a powerful protein that lies dormant within cells and is often described as, “The Guardian of Human Lifespan.” When Nrf2 is activated by select agents such as pure honokiol, it acts as a master regulator of antioxidant functions and healthy gene expression.

HonoPure® honokiol supplement from ecoNugenics contains 98% pure honokiol, the highest purity and potency of honokiol available. Pure honokiol crosses the blood-brain barrier and has been extensively researched for its unique mechanisms and benefits across numerous areas of health. This study adds to the growing body of data demonstrating the efficacy of this extract for supporting cognitive function, relaxation, mood, and neurological health–safely and naturally.*


A powerful, versatile extract that provides a broad-spectrum of critical benefits for neurological function, oncology support, and other key areas of health.*



Hou Y, et al. ACS Chem Neurosci. 2018 Jul 10.